
Sildenafil
/mo
When consistency starts to change.

How sildenafil affects blood flow.
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What system does sildenafil primarily affect?
Its primary action is on vascular smooth muscle, specifically within the nitric oxide–cGMP pathway.
Why does sildenafil require stimulation to work?
It enhances the body’s existing nitric oxide response but does not initiate it. Without sexual stimulation, the signaling pathway it acts on is not activated.
How does sildenafil improve erectile function?
Sildenafil inhibits the PDE5 enzyme, which increases levels of cGMP. This allows nitric oxide–mediated vasodilation to last longer, improving blood flow to erectile tissue during sexual stimulation.
How quickly does sildenafil take effect?
It is typically absorbed within 30 to 60 minutes, though timing can vary based on factors like food intake and individual metabolism.

